Asthma, Histamine and the Gut

by | Jul 29, 2021 | Articles

What are the Symptoms of Asthma?

By Zoe Hunt (BPharm, BNatMed) [Ed: Sharon Erdrich]

Symptoms of asthma can include wheezing, coughing (which may nor may not be productive), shortness of breath, tightness in the chest and fatigue. Sometimes the only sign of asthma can be an ongoing night-time cough. Both genetics and environmental exposures (such as irritants or allergens) are involved 1, 3.

An acute asthmatic episode can be life threatening. Symptoms to look for in an acute asthma attack include 3:

  • Difficulty speaking. If a person is having difficulty finishing sentences without taking another breath, or is only able to say one or two words at a time.
  • This is a whistling noise, most commonly with breathing out, but can also happen with an in-breath. If other symptoms are still present and wheezing disappears this is a medical emergency – call 111
  • Sucking in. This indrawing can be seen at the base of the neck, between the ribs or in the abdomen. Instead of the tummy going out with an in-breath, it is sucked in.
  • Blueness around the mouth and fingertips. If this is happening, the person is not getting enough oxygen. Dial 111
  • Increased breathing rate
  • Hunching over. Leaning forward increases the expansion of the ribcage in the back.

Read more about Asthma here

Please note, not all symptoms need to be present.

A lot of research has been conducted on asthma in the last decade. As asthma is a complex disease, the word asthma is now classed as an umbrella term with subtypes beneath it 6. Within the “asthma umbrella” there are different characteristics, or presentations of asthma – these are known as phenotypes 7, 8, 9.  An example of this would be the subtype of early-onset allergic asthma., which has different immune processes occurring in the background compared to adult-onset asthma caused by obesity or smoking 9.

Histamine Intolerance and Adult-onset Asthma

There is no doubt that histamine is associated with the pathophysiology of asthma. Histamine (and other inflammatory chemicals) can contract the smooth muscle of the airways, inducing swelling and mucous production. This leads to constricted airways and the symptoms of asthma 2, 10.

An enzyme called histamine N-methyltransferase (HNMT) is the main enzyme for breaking down histamine in the cells of our airways. Genetic differences in the HNMT gene may be involved in the development  of allergic asthma 11, 12.

The main enzyme that metabolises histamine in our gut is called diamine oxidase (DAO). Simply put, if the amount of histamine in the intestines, either from food or produced internally, is more than what the available DAO can process, people can experience symptoms of histamine intolerance. This looks just like typical allergy, with wheezing, nasal congestion, a runny nose, itchy skin and maybe even hives. Other symptoms can include digestive issues, headache, and low blood pressure 13.

Reasons that DAO histamine metabolism can be impaired include:

  • An inflamed, damaged and/or leaky gut
  • Genetics (less common)
  • Foods that block DAO production or function – alcohol, energy drinks & caffeine (including tea)
  • Medications that block DAO such as NSAIDs (which can also cause inflammation in the gut) 14

An imbalanced gut microbiome (dysbiosis) may see a high population of histamine-producing bacteria. Such bacteria have been found to be at higher concentrations in faecal samples in asthmatic patients 15. Dysbiosis also contributes to inflammation and intestinal hyper-permeability (leaky gut). In a leaky gut, the contents of the gut such as food proteins, bacteria and bacterial toxins can get through the gut wall into the blood stream where they can cause inflammation and dysregulated immune responses just like in asthma 16,14. You can see that an unbalanced microbiome can have widespread effects – beyond the gut itself! A healthy gut contributes enormously to reducing systemic inflammation and a balanced, healthy immune system 14.

Stress also has a role to play, not only with regard to anxiety induced asthma which changes our breathing patterns, but also constant stress has profound effects on our gut and immune health. When we experience stress our sympathetic nervous system takes control and via complex mechanisms the mast cells release histamine along our gut lining. This extra histamine, combined with increased cortisol production from our nervous system being in a sympathetic state, increases gut permeability leading to leaky gut and inflammation and a dysregulated immune response 17. The extra histamine production alone can lead to the above mentioned allergy like symptoms.

 

Asthma histamine Food

How do you Manage Histamine Intolerance?

Histamine intolerance is likely to be an underestimated problem, and there is a need for  more research in this area13. If you have asthma and/or any of the associated symptoms of histamine intolerance, and you have had a negative allergy test, this increases the likelihood you may have histamine intolerance.

Considerations for managing histamine intolerance:

  • Reduce foods that increase histamine levels (at least while correcting any underlying issues)

Examples include:

  • Fruits such as strawberries and citrus
  • Fermented foods (e.g., sauerkraut)
  • Aged cheese (e.g., blue/stilton)
  • Most vinegars
  • Some animal products, such as canned fish, processed meats, egg white, smoked fish
  • Chemicals such as tartazines & benzoates
  • Cocoa and chocolate 14

Please note this list is not extensive and it is best to work with a practitioner.

A qualified practitioner at House of Health / The Auckland Gut Clinic will work with you to;

  • Manage your current symptoms
  • Achieve a healthy gut microbiome
  • Reduce leaky gut and gut inflammation
  • Help you manage your stress
  • Stabilise mast cells 14

Cited References

  1. Papadopoulos, N. G., Arakawa, H., Carlsen, K. H., Custovic, A., Gern, J., Lemanske, R., … & Zeiger, R. S. (2012). International consensus on (ICON) pediatric asthma. Allergy, 67(8), 976-997.
  2. Agrawal, D. K., & Shao, Z. (2010). Pathogenesis of allergic airway inflammation. Current allergy and asthma reports, 10(1), 39–48. https://doi.org/10.1007/s11882-009-0081-7 
  3. Asthma New Zealand. (2021). What is asthma. https://www.asthma.org.nz/pages/what-is-asthma 
  4. Umetsu, D. T., & DeKruyff, R. H. (2006). Immune dysregulation in asthma. Current opinion in immunology, 18(6), 727-732.
  5. Asthma and Respiratory Foundation NZ. (2021). Asthma. https://www.asthmafoundation.org.nz/your-health/living-with-asthma 
  6. Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., … & Bush, A. (2018). After asthma: redefining airways diseases. The Lancet, 391(10118), 350-400.
  7. Lötvall, J., Akdis, C. A., Bacharier, L. B., Bjermer, L., Casale, T. B., Custovic, A., … & Greenberger, P. A. (2011). Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. Journal of Allergy and Clinical Immunology, 127(2), 355-360.
  8. Hough, K. P., Curtiss, M. L., Blain, T. J., Liu, R. M., Trevor, J., Deshane, J. S., & Thannickal, V. J. (2020). Airway remodeling in asthma. Frontiers in Medicine, 7.
  9. Carr, T. F., Zeki, A. A., & Kraft, M. (2018). Eosinophilic and noneosinophilic asthma. American journal of respiratory and critical care medicine, 197(1), 22-37.
  10. Vassilopoulou, E., Konstantinou, G. N., Dimitriou, A., Manios, Y., Koumbi, L., & Papadopoulos, N. G. (2020). The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study. Nutrients, 12(11), 3402.
  11. Yamauchi, K., & Ogasawara, M. (2019). The role of histamine in the pathophysiology of asthma and the clinical efficacy of antihistamines in asthma therapy. International journal of molecular sciences, 20(7), 1733.
  12. Yan, L., Galinsky, R. E., Bernstein, J. A., Liggett, S. B., & Weinshilboum, R. M. (2000). Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Pharmacogenetics and Genomics, 10(3), 261-266.
  13. Maintz, L., & Novak, N. (2007). Histamine and histamine intolerance. The American Journal of Clinical Nutrition, 85(5), 1185-1196.
  14. Baden, D. (2018) Breaking the cycle of chronic allergies. Biomedica Webinar
  15. Barcik, W., Pugin, B., Westermann, P., Perez, N. R., Ferstl, R., Wawrzyniak, M., … & O’Mahony, L. (2016). Histamine-secreting microbes are increased in the gut of adult asthma patients. Journal of Allergy and Clinical Immunology, 138(5), 1491-1494.
  16. Kozik, A. J., & Huang, Y. J. (2019). The microbiome in asthma: role in pathogenesis, phenotype, and response to treatment. Annals of Allergy, Asthma & Immunology, 122(3), 270-275.
  17. Heyman, A. (2015). Stress – a multisystem disorder. FX Med Webinar

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